OS9抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, 231 cells, NIH/3T3 cells, Primary antibody: P08588(OS9 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08588(OS9 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

OS9 antibody is a research tool targeting OS-9 (osteosarcoma amplified 9), a protein implicated in endoplasmic reticulum (ER)-associated degradation (ERAD). OS-9 functions as a key component of the ER quality control system, identifying misfolded glycoproteins and directing them for proteasomal degradation via interactions with ER-resident lectins and E3 ubiquitin ligases like HRD1. It plays roles in maintaining ER homeostasis, regulating protein folding, and responding to cellular stress. Dysregulation of OS-9 is linked to diseases such as cancer, neurodegenerative disorders, and diabetes.

OS9 antibodies are widely used to study OS-9 expression, localization, and function in biological samples. They are applied in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate OS-9's involvement in pathological conditions. For example, OS-9 is overexpressed in certain cancers (e.g., glioblastoma, osteosarcoma), where it may promote tumor progression by modulating hypoxia-inducible factor (HIF) signaling or ER stress pathways. In neurodegenerative contexts, OS-9 variants are associated with inherited spastic paraplegia, highlighting its neuroprotective role. Researchers also utilize OS9 antibodies to explore therapeutic strategies targeting ERAD or stress-response pathways. Validated antibodies are critical for distinguishing OS-9 isoforms (OS-9-1 and OS-9-2) and ensuring specificity in experimental models. Its dual role as a disease biomarker and potential drug target underscores the importance of OS9 antibodies in both basic and translational research.