OLFM3抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse intestines tissue, Primary antibody: P08586(OLFM3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

The OLFM3 antibody is a tool used to detect OLFM3 (olfactomedin 3), a protein belonging to the olfactomedin domain-containing family. OLFM3 is involved in cell adhesion, neural development, and tissue morphogenesis, though its precise biological functions remain less characterized compared to other family members like OLFM4. Research suggests OLFM3 may play roles in cancer progression, with studies linking its expression to tumorigenesis in pancreatic, colorectal, and glioblastoma cancers. It is also implicated in regulating Wnt/β-catenin and other signaling pathways, influencing cell proliferation and differentiation.

The OLFM3 antibody, typically generated in rabbits or mice, is used in applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study OLFM3's expression patterns and subcellular localization. Its validation often includes knockout controls to confirm specificity. Commercially available antibodies aid in exploring OLFM3's diagnostic or prognostic potential, particularly in cancers where its expression correlates with clinical outcomes. However, limited studies and varying antibody performance across experimental conditions highlight the need for rigorous validation. Ongoing research aims to clarify OLFM3's mechanistic contributions to disease and normal physiology, positioning it as a potential therapeutic target or biomarker.