NDEL1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P08579(NDEL1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

NDEL1 (Nuclear Distribution Element-Like 1) is a crucial protein involved in neuronal development, cell cycle regulation, and microtubule dynamics. It interacts with key molecular components like LIS1 and dynein to regulate cytoplasmic dynein function, essential for proper neuronal migration, cortical layering, and neurogenesis. NDEL1 antibodies are vital tools for studying these processes, particularly in neurodevelopmental disorders such as lissencephaly and psychiatric conditions like schizophrenia.

These antibodies enable the detection and localization of NDEL1 in various experimental setups, including Western blotting, immunohistochemistry, and immunofluorescence. Researchers use them to investigate NDEL1's roles in mitosis, centrosome positioning, and synaptic function. In disease contexts, altered NDEL1 expression has been linked to neurological defects and cancer progression, making its antibodies valuable for diagnostic and mechanistic studies.

Commercial NDEL1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., amino acid residues 1-250). Validation includes testing in knockout models or siRNA-treated cells to ensure specificity. Recent studies also explore NDEL1's interaction with viral proteins, expanding its relevance to infectious diseases. Overall, NDEL1 antibodies serve as indispensable reagents for unraveling neurodevelopmental pathways and disease mechanisms.