HMGN5抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Raji cells, 293T cells, Hela cells, 231 cells, Primary antibody: P08576(HMGN5 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

HMGN5 antibody is a research tool designed to detect and study the High Mobility Group Nucleosome-binding protein 5 (HMGN5), a member of the HMGN family. HMGN proteins are chromatin-associated factors that regulate chromatin structure and gene expression by interacting with nucleosomes. HMGN5. also known as NSBP1 (Nucleosome-binding protein 1), is distinguished by its ability to bind nucleosomes and modulate chromatin accessibility, influencing DNA replication, repair, and transcriptional activity. It is ubiquitously expressed but shows elevated levels in certain cancers, including prostate, breast, and ovarian cancers, where it is implicated in promoting cell proliferation, invasion, and metastasis through interactions with pathways like Wnt/β-catenin or EGFR signaling.

HMGN5 antibodies are widely used in molecular and cellular biology to investigate the protein's expression patterns, subcellular localization, and functional mechanisms. These antibodies enable techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP), aiding in the study of HMGN5's role in epigenetic regulation and disease progression. Researchers also utilize HMGN5 antibodies to explore its potential as a therapeutic target or biomarker in cancer, leveraging experimental models like cell lines or xenografts. Validation of antibody specificity (e.g., via knockout controls) is critical to ensure accurate detection, given structural similarities among HMGN family members.