NECTIN2抗体—艾普蒂

The NECTIN2 antibody targets Nectin-2 (also known as PVRL2 or CD112), a cell adhesion molecule belonging to the nectin family. Nectin-2 is a transmembrane protein involved in forming adherens and tight junctions, facilitating cell-cell adhesion in epithelial and endothelial tissues. It also plays roles in immune regulation, viral entry (e.g., as a receptor for herpes simplex virus and pseudorabies virus), and synaptic organization. In cancer biology, NECTIN2 is overexpressed in certain tumors and interacts with immune checkpoint receptors like TIGIT and CD226. modulating anti-tumor immune responses. Antibodies against NECTIN2 are used to study its expression, localization, and function in normal and diseased tissues. Therapeutic NECTIN2-targeting antibodies, such as those blocking viral entry or enhancing immune activation, are under investigation. Research tools include monoclonal and polyclonal antibodies validated for techniques like immunohistochemistry, flow cytometry, and Western blot. Recent studies highlight its potential as a biomarker or therapeutic target in cancers and infectious diseases, driving interest in developing NECTIN2-specific biologics.