NDUFS6抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08558(NDUFS6 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The NDUFS6 antibody is a crucial tool for studying mitochondrial complex I (NADH:ubiquinone oxidoreductase), a key component of the electron transport chain (ETC) responsible for oxidative phosphorylation. NDUFS6 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 6) is a nuclear-encoded core subunit of complex I, playing a vital role in its assembly, stability, and catalytic activity. This subunit participates in electron transfer from NADH to ubiquinone, contributing to proton gradient generation and ATP synthesis. Dysfunction of NDUFS6 is linked to mitochondrial disorders, such as Leigh syndrome, cardiomyopathy, and neurodegenerative diseases, often caused by mutations that impair complex I function.

The NDUFS6 antibody specifically targets the NDUFS6 protein, enabling researchers to detect and quantify its expression in tissues or cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It is widely used to investigate mitochondrial dysfunction in metabolic diseases, aging, and cancer, where altered complex I activity is implicated. Additionally, the antibody aids in diagnosing genetic disorders associated with complex I deficiencies. Available as monoclonal or polyclonal versions, it is typically validated for cross-reactivity and specificity across species, including human, mouse, and rat models. Its application advances understanding of cellular bioenergetics and therapeutic strategies targeting mitochondrial pathologies.