CLIC1抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: P08542(CLIC1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P08542(CLIC1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08542(CLIC1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of CLIC1 Antibody**

The **Chloride Intracellular Channel 1 (CLIC1)** protein belongs to the CLIC family of chloride ion channels, which exhibit unique dual functionality as both soluble cytoplasmic proteins and integral membrane proteins. CLIC1 is implicated in diverse cellular processes, including ion homeostasis, cell cycle regulation, apoptosis, and cellular proliferation. Its redox-sensitive structure allows it to transition between soluble and membrane-bound states, influencing ion transport and intracellular signaling pathways.

CLIC1 antibodies are essential tools for detecting and studying the expression, localization, and functional roles of CLIC1 in physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. Research has highlighted CLIC1's overexpression in various cancers (e.g., glioblastoma, colorectal, and breast cancers), where it correlates with tumor progression, metastasis, and poor prognosis. This has spurred interest in CLIC1 as a potential therapeutic target or biomarker.

Additionally, CLIC1 antibodies aid in exploring its involvement in inflammatory diseases, neurological disorders, and oxidative stress responses. Studies also investigate its interaction with cytoskeletal components and signaling molecules, shedding light on its non-channel roles in cellular dynamics. As CLIC1's mechanistic complexity remains under active investigation, high-specificity antibodies remain critical for advancing its biological and clinical understanding.