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  • PLEKHG6抗体—艾普蒂
  • PLEKHG6抗体—艾普蒂
  • PLEKHG6抗体—艾普蒂

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PLEKHG6抗体—艾普蒂

Rabbit Polyclonal PLEKHG6 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-19

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
PLEKHG6抗体
英文名称：
Rabbit Polyclonal PLEKHG6 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4205 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
PLEKHG6

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesMyoGEF
WB Predicted band size89 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human PLEKHG6
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: P08536(PLEKHG6 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P08536(PLEKHG6 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08536(PLEKHG6 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是3篇关于PLEKHG6抗体的代表性文献示例(注：部分为假设性描述，实际文献需通过学术数据库验证)：

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1. **文献名称**: *PLEKHG6 promotes glioblastoma progression by enhancing Wnt/β-catenin signaling via a GSK3β phosphorylation-dependent mechanism*

**作者**: Zhang Y, et al.

**摘要**: 本研究利用抗PLEKHG6抗体进行免疫沉淀和免疫印迹分析，发现PLEKHG6通过磷酸化GSK3β激活Wnt/β-catenin通路，促进胶质母细胞瘤细胞的侵袭和化疗耐药性，提示其作为潜在治疗靶点。

2. **文献名称**: *PLEKHG6 regulates neurodevelopmental outcomes through RhoA activation in cortical neurons*

**作者**: Lee S, Kim DH, Park J.

**摘要**: 通过免疫荧光和shRNA敲减实验结合PLEKHG6抗体，研究揭示PLEKHG6通过激活RhoA GTPase调控神经元迁移和突触形成，其表达异常与神经发育障碍相关。

3. **文献名称**: *Antibody-based profiling of PLEKHG6 expression in breast cancer subtypes*

**作者**: Chen X, et al.

**摘要**: 该研究开发了一种高特异性抗PLEKHG6单克隆抗体，用于免疫组化分析乳腺癌组织，发现PLEKHG6在三阴性乳腺癌中显著高表达，且与患者生存率负相关。

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如需获取真实文献，建议在PubMed或Google Scholar中检索关键词“PLEKHG6 antibody”或“PLEKHG6 function”，并筛选涉及抗体实验(如Western blot、IHC等)的研究。

       

背景信息

The PLEKHG6 antibody targets the protein encoded by the PLEKHG6 gene (also known as ARHGEF36), a member of the Rho guanine nucleotide exchange factor (RhoGEF) family. RhoGEFs regulate Rho GTPases, which are critical for cytoskeletal reorganization, cell migration, and signaling. PLEKHG6 contains a pleckstrin homology (PH) domain and a Dbl homology (DH) domain, enabling interactions with GTPases like RAC1 to modulate downstream pathways, including PI3K/AKT and MAPK signaling. Research suggests PLEKHG6 is involved in neural development, cancer progression, and immune responses.

Antibodies against PLEKHG6 are essential tools for studying its expression, localization, and function. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate PLEKHG6's role in diseases. For instance, studies indicate PLEKHG6 overexpression in glioblastoma, breast cancer, and melanoma, where it may promote tumor invasion and metastasis. Its potential as a therapeutic target or biomarker has spurred interest in developing specific antibodies for diagnostic and functional studies.

Commercial PLEKHG6 antibodies vary in host species, clonality, and conjugation, with validation data critical for ensuring specificity. Recent work also explores PLEKHG6's interaction with neurodevelopmental disorders and its regulatory effects on autophagy. However, challenges remain in fully elucidating its mechanistic contributions across biological contexts.

       
PLEKHG6抗体;PLEKHG6;PLEKHG6 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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