MRPL12抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: P08522(MRPL12 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08522(MRPL12 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P08522(MRPL12 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The mitochondrial ribosomal protein L12 (MRPL12) is a key component of the large subunit of the mitochondrial ribosome (mitoribosome), which is essential for protein synthesis within mitochondria. Encoded by nuclear DNA, MRPL12 is imported into mitochondria and plays a critical role in assembling and stabilizing the mitoribosome structure. Beyond its ribosomal function, MRPL12 interacts with mitochondrial RNA polymerase (POLRMT) to regulate mitochondrial transcription, linking translation and transcription processes in mitochondrial gene expression.

MRPL12 antibodies are widely used tools to investigate mitochondrial dysfunction, energy metabolism, and diseases associated with mitoribosome anomalies, such as cancer, neurodegenerative disorders, and mitochondrial encephalopathies. These antibodies enable the detection of MRPL12 expression levels, subcellular localization (via immunofluorescence or immunohistochemistry), and protein-protein interactions (via co-immunoprecipitation or Western blot). Studies using MRPL12 antibodies have revealed its role in maintaining mitochondrial DNA integrity, oxidative phosphorylation efficiency, and cellular stress responses.

Dysregulation of MRPL12 has been implicated in tumor progression, metabolic syndromes, and aging, making its antibody a valuable reagent for both basic research and clinical diagnostics. Specificity validation (e.g., knockout controls) is critical due to potential cross-reactivity with cytoplasmic ribosomal proteins. Overall, MRPL12 antibodies contribute to understanding mitochondrial biology and its intersection with human health.