CENPU抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08520(CENPU Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08520(CENPU Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The CENPU antibody is a research tool targeting Centromere Protein U (CENPU), a critical component of the centromere-associated network essential for mitotic and meiotic chromosome segregation. CENPU, also known as ICEN36 or MLF1IP, plays a pivotal role in kinetochore assembly and stabilization by interacting with other centromeric proteins like CENPA and CENPC. It facilitates proper microtubule attachment to chromosomes, ensuring accurate distribution of genetic material during cell division. Dysregulation of CENPU is linked to genomic instability, mitotic errors, and carcinogenesis, with overexpression observed in various cancers, including hepatocellular carcinoma and leukemia, suggesting its potential as a diagnostic or prognostic marker.

CENPU antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to study protein expression, localization, and functional dynamics in cellular models or clinical samples. Researchers employ these antibodies to explore CENPU's role in cell cycle regulation, its interactions within the centromere-kinetochore complex, and its contribution to tumor progression. Additionally, they support drug discovery efforts targeting CENPU to disrupt aberrant cell proliferation in cancers. As a key reagent in molecular and cancer biology, the CENPU antibody enhances understanding of chromosomal mechanics and their implications in disease.