GHITM抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08517(GHITM Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

GHITM (Growth Hormone-Inducible Transmembrane Protein), also known as HSPA12B, is a conserved transmembrane protein belonging to the HSP70 family. It localizes to mitochondria and endoplasmic reticulum (ER) membranes, playing critical roles in cellular stress responses, mitochondrial morphology regulation, apoptosis, and metabolic homeostasis. Studies link GHITM to mitochondrial-associated ER membrane (MAM) contact sites, where it influences calcium signaling, lipid transfer, and mitochondrial dynamics. Its involvement in maintaining mitochondrial cristae structure and cytochrome c release underscores its dual role in promoting or inhibiting apoptosis, depending on cellular context.

GHITM antibodies are essential tools for detecting and studying this protein's expression, localization, and function. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate GHITM's association with diseases. Research implicates GHITM dysregulation in cardiovascular disorders (e.g., heart failure), neurodegenerative conditions (e.g., Alzheimer's), and cancer, where its expression often correlates with tumor progression or chemoresistance. Validated GHITM antibodies typically undergo specificity checks using knockout/knockdown models or peptide blocking assays. Recent studies also explore its potential as a biomarker or therapeutic target, particularly in mitochondrial dysfunction-related pathologies. Proper antibody selection remains crucial due to protein homology within the HSP70 family.