ZC3H12A抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: K562 cells, Primary antibody: P08502(ZC3H12A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08502(ZC3H12A Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08502(ZC3H12A Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ZC3H12A antibody is a crucial tool for studying the ZC3H12A protein, also known as MCPIP1 (monocyte chemotactic protein-induced protein 1), which plays a vital role in immune regulation, inflammation, and cell death. ZC3H12A is a CCCH-type zinc finger protein with ribonuclease activity, involved in degrading specific mRNAs to control inflammatory responses. It regulates cytokines like IL-6 and IL-12β by modulating NF-κB and AP-1 signaling pathways, and it influences autophagy and apoptosis. Dysregulation of ZC3H12A is linked to autoimmune diseases, cancer, and metabolic disorders.

Antibodies targeting ZC3H12A are widely used in Western blotting, immunohistochemistry, immunoprecipitation, and immunofluorescence to detect protein expression, localization, and interactions. Researchers rely on these antibodies to explore ZC3H12A's role in immune homeostasis, its anti-inflammatory effects, and its tumor-suppressive or oncogenic functions in different contexts. Validated antibodies are essential, as ZC3H12A shares structural homology with other family members (e.g., ZC3H12B-D), requiring specificity checks via knockout controls. Host species (rabbit, mouse), clonality (monoclonal/polyclonal), and epitope regions vary across commercial antibodies, impacting experimental outcomes. Studies using ZC3H12A antibodies have advanced understanding of its post-transcriptional regulatory mechanisms in vivo, particularly in murine models of inflammation, atherosclerosis, and cancer. Proper antibody selection ensures accurate detection of both full-length protein and cleaved isoforms, critical for functional studies.