TAB3抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Raw264.7 cells, Primary antibody: P08496(TAB3 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08496(TAB3 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08496(TAB3 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The TAB3 (TGF-β-activated kinase 1 and MAP3K7-binding protein 3) antibody is a research tool used to study the TAB3 protein, a key adaptor molecule in the NF-κB and MAPK signaling pathways. TAB3. along with its homolog TAB2. binds to TAK1 (TGF-β-activated kinase 1) through its C-terminal conserved domain, facilitating TAK1 activation in response to pro-inflammatory cytokines (e.g., TNF-α, IL-1) or pathogen-associated molecular patterns. This interaction triggers downstream signaling cascades that regulate immune responses, cell survival, and apoptosis. Structurally, TAB3 contains an N-terminal ubiquitin-binding domain and a C-terminal TAK1-binding domain, enabling its role in linking upstream signaling events to kinase activation.

TAB3 is functionally redundant with TAB2 but exhibits tissue-specific expression patterns, suggesting context-dependent roles. Dysregulation of TAB3 has been implicated in inflammatory diseases, cancer (e.g., breast, liver), and autoimmune disorders due to its impact on NF-κB-driven gene expression. Researchers use TAB3 antibodies in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, post-translational modifications (e.g., ubiquitination), and interactions with signaling partners like TRAF6 or TAK1. These studies aim to uncover mechanisms underlying inflammation, oncogenesis, and potential therapeutic targets. Commercial TAB3 antibodies are typically validated for specificity in human, mouse, or rat models, supporting both basic research and translational applications.