KLK8抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08468(KLK8 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08468(KLK8 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

**Background of KLK8 Antibody**

Kallikrein-related peptidase 8 (KLK8), also known as neuropsin, is a serine protease encoded by the *KLK8* gene, part of the kallikrein (KLK) family located on chromosome 19q13.4. The KLK family comprises 15 secreted enzymes involved in diverse physiological processes, including skin desquamation, inflammation, and cancer progression. KLK8 is expressed in various tissues, notably the brain, skin, and reproductive organs, and plays roles in synaptic plasticity, epidermal barrier function, and tumor microenvironment modulation. Dysregulation of KLK8 has been linked to neurodegenerative disorders (e.g., Alzheimer’s disease), inflammatory skin conditions, and cancers (e.g., ovarian, breast).

KLK8 antibodies are immunological tools developed to detect and quantify KLK8 protein levels in research and diagnostics. These antibodies (monoclonal or polyclonal) are generated using immunogenic peptides or recombinant KLK8 proteins. They enable applications like ELISA, immunohistochemistry, and Western blotting to study KLK8 expression, localization, and functional roles. In cancer research, KLK8 antibodies help evaluate its dual role as both a tumor promoter (via extracellular matrix degradation) and suppressor (through protease-activated receptor signaling). Challenges in antibody development include ensuring specificity due to structural homology among KLK family members. Validated KLK8 antibodies are critical for exploring its potential as a biomarker or therapeutic target in precision medicine.