JAKMIP2抗体—艾普蒂

The JAKMIP2 (Janus Kinase and Microtubule-Interacting Protein 2) antibody is a tool used to study the JAKMIP2 protein, a member of the JAKMIP family implicated in neuronal development and synaptic function. JAKMIP2 contains conserved domains that facilitate interactions with Janus kinases (JAKs) and microtubule networks, linking it to JAK-STAT signaling pathways and cytoskeletal dynamics. It is predominantly expressed in the brain, where it regulates neuronal migration, axon guidance, and synaptic plasticity by modulating JAK-STAT activity and microtubule stability. Dysregulation of JAKMIP2 has been associated with neurodevelopmental disorders, including autism spectrum disorders and epilepsy. The antibody enables detection and localization of JAKMIP2 in tissues or cells via techniques like Western blot, immunohistochemistry, and immunofluorescence. Researchers utilize it to explore JAKMIP2’s role in cellular signaling, its interaction partners, and its potential as a biomarker or therapeutic target in neurological diseases. Commercial JAKMIP2 antibodies are typically developed in hosts like rabbits or mice, validated for specificity against recombinant or endogenous protein epitopes. Ongoing studies focus on elucidating its molecular mechanisms in health and disease contexts.