TXLNA抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cells, 293T cells, Primary antibody: P08435(TXLNA Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08435(TXLNA Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The TXLNA antibody targets thioredoxin-like protein 1 (TXLNA), a member of the thioredoxin family known for its role in redox regulation and cellular homeostasis. Thioredoxins are small, evolutionarily conserved proteins that modulate oxidative stress by catalyzing disulfide bond reduction, thereby influencing processes like DNA synthesis, apoptosis, and immune response. TXLNA, also referred to as TXNL1 or TRP32. shares structural and functional similarities with thioredoxin but exhibits distinct tissue expression patterns, particularly in the brain, liver, and reproductive organs.

Research on TXLNA has linked it to neurodegenerative diseases, cancer, and metabolic disorders due to its involvement in antioxidant defense and protein folding. For example, dysregulation of TXLNA has been observed in Alzheimer’s disease, where oxidative stress contributes to neuronal damage, and in certain cancers, where it may promote tumor survival under hypoxic conditions.

TXLNA antibodies are essential tools for studying these mechanisms. They enable detection and quantification of TXLNA in biological samples via techniques like Western blotting, immunohistochemistry, and ELISA. Such antibodies are also used to explore TXLNA’s interactions with other redox-regulating proteins or its role in signaling pathways. Commercially available antibodies are typically validated for specificity and sensitivity, often in multiple species, to support translational research. Understanding TXLNA’s functions through antibody-based assays could aid in developing diagnostic biomarkers or therapies targeting oxidative stress-related pathologies.