MX1抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: P08428(MX1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

The MX1 antibody targets the MX1 protein (Myxovirus resistance 1), also known as MxA, a key component of the innate immune system. Discovered in the 1960s for its role in conferring resistance to influenza viruses, MX1 is an interferon-inducible GTPase that inhibits viral replication, particularly against RNA viruses like influenza, measles, and hepatitis B. Structurally, MX1 contains an N-terminal GTPase domain and a C-terminal effector domain, enabling it to oligomerize and disrupt viral nucleocapsids.

MX1 antibodies are widely used in research to study antiviral defense mechanisms, interferon signaling, and immune dysregulation. They help detect MX1 expression in cells or tissues via techniques like Western blot, immunohistochemistry, and immunofluorescence. Elevated MX1 levels are often linked to enhanced antiviral activity, while its overexpression in autoimmune diseases (e.g., lupus, dermatomyositis) suggests a connection to dysregulated interferon pathways.

These antibodies also contribute to exploring MX1's dual role: while protective against viruses, its persistent activation may drive chronic inflammation. Recent studies investigate MX1 as a biomarker for interferon-related disorders and a potential therapeutic target. Overall, MX1 antibodies are critical tools for dissecting the interplay between host immunity, viral evasion, and autoimmune pathogenesis.