HYAL3抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human kidney tissue, Primary antibody: P08423(HYAL3 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P08423(HYAL3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08423(HYAL3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

HYAL3 antibodies are immunological tools used to detect and study HYAL3. a member of the hyaluronidase enzyme family. HYAL3 (hyaluronidase 3) is one of six human hyaluronidases that degrade hyaluronic acid (HA), a major glycosaminoglycan in the extracellular matrix. While its enzymatic activity is less characterized compared to HYAL1 or HYAL2. HYAL3 is believed to play roles in HA turnover, tissue remodeling, and possibly cancer progression. It is expressed in various tissues, including the testes, placenta, and certain tumors.

Research suggests HYAL3 may have dual roles in cancer biology, acting as a tumor suppressor or oncogene depending on the cancer type. For example, HYAL3 upregulation has been linked to prostate and colorectal cancer aggressiveness, while its downregulation is observed in some lung and ovarian cancers. HYAL3 antibodies, typically developed as monoclonal or polyclonal reagents, enable researchers to investigate these associations through techniques like immunohistochemistry, Western blotting, and ELISA. Such studies aim to clarify HYAL3's involvement in tumor microenvironment modulation, metastasis, and its potential as a diagnostic or prognostic biomarker. Recent work also explores HYAL3's interactions with other hyaluronidases and its therapeutic targeting in HA-dependent pathologies. However, functional ambiguities persist due to overlapping substrate specificities within the enzyme family and context-dependent expression patterns.