SUV39H1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A549 cell lysate, Primary antibody: P08399(SUV39H1 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 25 seconds    

  
  

The SUV39H1 antibody is a crucial tool in epigenetics research, targeting the Suppressor of Variegation 3-9 Homolog 1 protein, a conserved histone methyltransferase. SUV39H1 catalyzes trimethylation of histone H3 at lysine 9 (H3K9me3), a hallmark of heterochromatin formation and gene silencing. First identified in *Drosophila* as a regulator of position-effect variegation, mammalian SUV39H1 plays key roles in chromatin organization, X-chromosome inactivation, and genomic stability.

This antibody is widely used to study SUV39H1's function in cell differentiation, cancer biology, and aging. It enables detection of protein expression levels, subcellular localization (primarily nucleus), and interaction partners through techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Researchers employ it to investigate SUV39H1's dual role in tumor suppression (via heterochromatin maintenance) and potential oncogenic activity (through aberrant gene silencing).

Commercial variants include monoclonal and polyclonal formats, with validation typically performed in knockout cell lines. Proper controls are essential due to cross-reactivity risks with related methyltransferases. Recent studies highlight its relevance in viral defense mechanisms, stem cell pluripotency, and metabolic reprogramming, making this antibody vital for dissecting epigenetic regulation in health and disease.