H2AC12抗体—艾普蒂

The H2AC12 antibody targets histone H2A variant C12 (H2A.C12), a member of the H2A histone family involved in chromatin structure and epigenetic regulation. Histones are core components of nucleosomes, playing essential roles in DNA packaging, gene expression, and cellular processes like replication and repair. H2A variants, including H2A.C12. exhibit sequence variations that influence nucleosome stability and interactions with chromatin-associated proteins. The H2AC12 antibody is commonly used to investigate H2A.C12's specific functions in chromatin organization, transcriptional regulation, and cellular differentiation. It is applied in techniques such as chromatin immunoprecipitation (ChIP), immunofluorescence, and Western blotting to study its localization, expression patterns, and post-translational modifications. Research involving H2AC12 may provide insights into developmental biology, stem cell dynamics, and diseases linked to chromatin dysregulation, such as cancer. This antibody's specificity makes it a valuable tool for dissecting the role of histone variants in maintaining genomic integrity and mediating epigenetic inheritance.