GSTA3抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: MCF7 cell lysate, Primary antibody: P08388(GSTA3 Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P08388(GSTA3 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The glutathione S-transferase alpha 3 (GSTA3) antibody is a tool used to detect and study the GSTA3 protein, a member of the glutathione S-transferase (GST) family. GSTs are phase II detoxification enzymes that catalyze the conjugation of glutathione to electrophilic substrates, facilitating their elimination and protecting cells from oxidative stress, toxins, and carcinogens. GSTA3. specifically, is part of the GST Alpha class, primarily expressed in the liver, kidneys, and other metabolically active tissues. It plays a critical role in neutralizing reactive oxygen species (ROS) and metabolizing xenobiotics, including drugs and environmental pollutants.

Research on GSTA3 has highlighted its involvement in cellular defense mechanisms, with implications in cancer, neurodegenerative diseases, and chemical-induced toxicity. Dysregulation of GSTA3 expression has been associated with drug resistance in certain cancers and susceptibility to oxidative damage in chronic diseases. The GSTA3 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate protein expression, localization, and function in both normal and pathological conditions. It aids in understanding tissue-specific detoxification pathways, biomarker discovery, and evaluating therapeutic interventions targeting GST-mediated pathways. Commercial GSTA3 antibodies are typically raised in hosts like rabbits or mice, validated for specificity against recombinant or endogenous GSTA3 across species.