NDUFA13抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Mouse spleen tissue, Mouse skeletal muscle tissue, human hepatocellular carcinoma tissue, mouse liver tissue, human placenta tissue, Hela cells, 293T cells, Primary antibody: P08385(NDUFA13 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P08385(NDUFA13 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08385(NDUFA13 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

**Background of NDUFA13 Antibody**

NDUFA13 (NADH:ubiquinone oxidoreductase subunit A13) is a nuclear-encoded subunit of mitochondrial Complex I, a critical component of the electron transport chain (ETC) responsible for oxidative phosphorylation. As part of the NADH dehydrogenase complex, NDUFA13 contributes to the structural stability and catalytic activity of Complex I, which transfers electrons from NADH to ubiquinone, driving ATP synthesis.

Antibodies targeting NDUFA13 are essential tools for studying mitochondrial function, Complex I assembly, and cellular energy metabolism. These antibodies enable the detection and quantification of NDUFA13 protein levels in tissues or cells via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Dysregulation of NDUFA13 or Complex I deficiency has been linked to mitochondrial disorders (e.g., Leigh syndrome), neurodegenerative diseases, and cancer, making such antibodies valuable for both research and clinical diagnostics.

NDUFA13 antibodies are typically raised in host species like rabbits or mice, with validation in specific applications to ensure specificity. Researchers use them to explore mechanisms underlying mitochondrial dysfunction, metabolic reprogramming in cancer, and responses to oxidative stress. Additionally, they aid in identifying biomarkers for diseases associated with impaired energy production. Overall, NDUFA13 antibodies are pivotal in advancing our understanding of mitochondrial biology and its implications in health and disease.