GP1BA抗体—艾普蒂

The GP1BA antibody targets glycoprotein Ibα (GP1BA), a critical subunit of the platelet membrane glycoprotein Ib-IX-V complex. This complex plays a central role in primary hemostasis by mediating platelet adhesion to von Willebrand factor (vWF) at sites of vascular injury. GP1BA, encoded by the GP1BA gene, forms the ligand-binding domain of the complex, enabling platelet interaction with subendothelial vWF under high shear stress. Antibodies against GP1BA are clinically significant in autoimmune disorders such as immune thrombocytopenia (ITP), where they accelerate platelet clearance, leading to thrombocytopenia and bleeding risk. Additionally, GP1BA autoantibodies are implicated in rare conditions like acquired Bernard-Soulier syndrome, mimicking the genetic defect in the GP1BA complex. Beyond pathology, GP1BA antibodies serve as research tools to study platelet activation mechanisms or diagnose platelet-related disorders. Detection methods like flow cytometry or ELISA utilize these antibodies to quantify GP1BA expression or identify autoantibodies in patient sera. Recent studies also explore their therapeutic potential, such as blocking pathological platelet aggregation in thrombosis. Understanding GP1BA antibodies bridges insights into platelet biology, autoimmune hematologic diseases, and diagnostic or therapeutic innovations.