ABL1抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07064(ABL1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The ABL1 antibody is a crucial tool in studying the ABL1 tyrosine kinase, encoded by the ABL1 gene located on chromosome 9. ABL1 plays a key role in regulating cell proliferation, differentiation, adhesion, and stress response. Dysregulation of ABL1. particularly through the BCR-ABL1 fusion protein resulting from the Philadelphia chromosome (t(9;22) translocation), is a hallmark of chronic myeloid leukemia (CML) and some acute lymphoblastic leukemias (ALL). ABL1 antibodies are designed to detect either the wild-type ABL1 protein or its oncogenic variants, enabling research into their signaling mechanisms and therapeutic targeting.

These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to analyze ABL1 expression, activation status (via phosphorylation), and subcellular localization. In clinical diagnostics, they aid in confirming BCR-ABL1 presence and monitoring treatment response to tyrosine kinase inhibitors (TKIs) like imatinib. Additionally, ABL1 antibodies help identify resistance mutations in the kinase domain that compromise TKI efficacy.

Epitope-specific ABL1 antibodies targeting functional domains (e.g., SH3. SH2. kinase) provide insights into structural and regulatory interactions. Their applications span basic cancer biology, drug development, and personalized oncology, making them indispensable for understanding ABL1-driven pathologies and advancing precision therapies.