APIP抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: Mouse heart tissue, Primary antibody: P07034(APIP Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07034(APIP Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

APIP (Apoptotic Protease-Activating Factor-1 (Apaf-1) Interacting Protein) is a mitochondrial protein involved in regulating cell death and metabolic pathways. Initially identified as an interactor of Apaf-1. it modulates apoptosis by competing with cytochrome c for Apaf-1 binding, thereby influencing caspase activation and mitochondrial apoptotic signaling. Beyond apoptosis, APIP is implicated in methionine metabolism, functioning as a methylthioribulose-1-phosphate dehydratase in the methionine salvage pathway. This dual role links APIP to cellular homeostasis, energy balance, and redox regulation.

Dysregulation of APIP has been associated with various diseases. Reduced APIP expression correlates with increased apoptosis in neurodegenerative conditions, while its overexpression is observed in certain cancers, suggesting context-dependent roles in cell survival. APIP antibodies are essential tools for studying these mechanisms, enabling detection of protein expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Such research aids in elucidating APIP's contribution to pathological processes, including tumor progression, metabolic disorders, and inflammatory responses. Current studies focus on its therapeutic potential, exploring APIP-targeted strategies to modulate cell death pathways or metabolic reprogramming in disease models.