SLC47A1抗体—艾普蒂

The solute carrier family 47 member 1 (SLC47A1), also known as multidrug and toxin extrusion protein 1 (MATE1), is a transmembrane transporter encoded by the SLC47A1 gene. It plays a critical role in the excretion of organic cations, including various endogenous compounds and xenobiotics, across renal and hepatic membranes. MATE1 works in tandem with other transporters (e.g., OCT2) to mediate the final step of drug elimination via proton gradient-driven efflux, impacting pharmacokinetics and drug-drug interactions. Antibodies targeting SLC47A1/MATE1 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. These antibodies, often developed against specific epitopes (e.g., cytoplasmic or extracellular domains), enable detection through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research applications include investigating tissue-specific distribution, regulatory mechanisms (e.g., transcriptional control by hormones or drugs), and associations with diseases such as chronic kidney disease, diabetes, or cancer. SLC47A1 dysregulation has been linked to altered drug responses, including chemotherapeutic resistance, making its antibodies valuable in pharmacogenomics and toxicology studies. Validation of antibody specificity (via knockout controls or siRNA) is critical due to potential cross-reactivity with homologous transporters like MATE2-K. Commercial SLC47A1 antibodies are widely used in both basic research and drug development to explore its role as a biomarker or therapeutic target.