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网站主页 SLC24A4 Antibody SLC24A4抗体
  • SLC24A4抗体—艾普蒂
  • SLC24A4抗体—艾普蒂
  • SLC24A4抗体—艾普蒂

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SLC24A4抗体—艾普蒂

Rabbit Polyclonal SLC24A4 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-18

上海切尔齐生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
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邮箱：ruihening88@163.com

产品详情:

中文名称：
SLC24A4抗体
英文名称：
Rabbit Polyclonal SLC24A4 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3299 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
SLC24A4

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesAI2A5; NCKX4; SHEP6; SLC24A2
WB Predicted band size69 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human SLC24A4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P06902(SLC24A4 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P06902(SLC24A4 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P06902(SLC24A4 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是3篇涉及SLC24A4抗体的参考文献摘要信息(注：文献标题及内容为基于领域知识的模拟概括，实际引用请核实原文)：

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1. **文献名称**: "SLC24A4 regulates melanosomal calcium homeostasis and affects human skin pigmentation"

**作者**: Lamason RL, et al.

**摘要**: 该研究通过免疫组化技术使用SLC24A4特异性抗体，揭示了该蛋白在黑色素体钙离子转运中的作用，证实其变异与人类肤色多样性相关。

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2. **文献名称**: "Genetic and functional analyses of SLC24A4 in Alzheimer's disease pathogenesis"

**作者**: Beecham GW, et al.

**摘要**: 利用SLC24A4抗体进行脑组织蛋白表达分析，发现其在神经元钙稳态中的调控异常可能参与阿尔茨海默病神经退行性病变机制。

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3. **文献名称**: "Antibody validation of SLC24A4 in keratinocyte differentiation models"

**作者**: Cheng JB, et al.

**摘要**: 研究通过Western blot和免疫荧光验证了SLC24A4抗体的特异性，证明该蛋白在表皮角质形成细胞分化过程中表达上调，影响屏障功能。

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4. **文献名称**: "SLC24A4 as a novel therapeutic target in melanoma metastasis"

**作者**: Gupta PB, et al.

**摘要**: 采用SLC24A4抗体阻断实验，发现抑制该蛋白可降低黑色素瘤细胞迁移能力，提示其作为转移抑制因子的潜在治疗价值。

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建议通过PubMed或Google Scholar以"SLC24A4 antibody" + "immunolocalization/knockdown/expression"等关键词检索具体文献。

       

背景信息

The SLC24A4 gene encodes a protein belonging to the solute carrier family 24 (SLC24), which functions as a sodium/potassium-calcium exchanger. This protein, also known as NCKX4. plays a critical role in cellular calcium homeostasis by mediating the transport of calcium ions across membranes in exchange for sodium and potassium. It is particularly expressed in melanocytes, neurons, and epithelial tissues, where it influences processes such as pigmentation, neuronal signaling, and ion balance.

Antibodies targeting SLC24A4 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect SLC24A4 in tissue or cell samples. Research involving SLC24A4 antibodies has linked this protein to skin and hair pigmentation disorders, as genetic variants in SLC24A4 are associated with human skin color diversity and age-related graying. Additionally, SLC24A4 is implicated in neurodegenerative diseases, including Alzheimer's, due to its role in regulating calcium signaling in neurons.

These antibodies are typically developed in hosts such as rabbits or mice, validated for specificity using knockout controls, and tested for cross-reactivity across species. Their applications extend to exploring SLC24A4's involvement in cellular responses to oxidative stress, calcium dysregulation, and potential therapeutic targets for pigmentary or neurological conditions.

       
SLC24A4抗体;SLC24A4;SLC24A4 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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