COX6A1抗体—艾普蒂

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     Western blot analysis using LPL mouse mAb against Hela cell lysate (1).    

  
  

The COX6A1 (Cytochrome c Oxidase Subunit 6A1) antibody is a tool used to detect the presence and expression levels of the COX6A1 protein, a critical component of Complex IV (cytochrome c oxidase) in the mitochondrial electron transport chain. COX6A1 is a nuclear-encoded subunit that contributes to the assembly and catalytic activity of Complex IV, which facilitates the final step of oxidative phosphorylation by transferring electrons to oxygen, generating water and driving ATP synthesis. Dysregulation of COX6A1 has been implicated in various pathologies, including cancers, neurodegenerative disorders, and mitochondrial diseases, due to its role in cellular energy metabolism.

COX6A1 antibodies are commonly utilized in research to investigate mitochondrial function, cellular bioenergetics, and disease mechanisms. They are employed in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression patterns in tissues, cell lines, or experimental models. These antibodies are often raised in host species like rabbits or mice, with specificity validated through knockout controls or peptide blocking assays. Commercial variants may include monoclonal or polyclonal formats, with applications spanning basic research, biomarker discovery, and therapeutic target validation. Understanding COX6A1 expression dynamics provides insights into metabolic adaptations in diseases, making its antibody a valuable resource in mitochondrial and translational research.