KRT36抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human skin tissue lysate, Primary antibody: P06814(KRT36 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P06814(KRT36 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06814(KRT36 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The KRT36 antibody targets keratin 36. a member of the type I acidic keratin family encoded by the *KRT36* gene. Keratins are structural proteins critical for maintaining the integrity of epithelial cells, particularly in hair, nails, and skin. KRT36 is primarily expressed in the hair cortex and cuticle, where it contributes to hair shaft strength and resilience. It pairs with type II keratins (e.g., KRT85) to form intermediate filaments, essential for cellular mechanical stability.

Research on KRT36 has focused on its role in hair disorders and ectodermal dysplasias. Mutations in *KRT36* or its binding partners are linked to conditions like monilethrix (beaded hair) or hereditary hair loss. The KRT36 antibody is a vital tool for studying these pathologies, enabling detection of protein expression patterns in tissues via immunohistochemistry, Western blotting, or immunofluorescence.

Clinically, this antibody aids in diagnosing genetic hair disorders by identifying abnormal keratin expression. It also supports research into regenerative therapies targeting hair follicle regeneration. Recent studies explore KRT36's potential interactions with signaling pathways in epithelial differentiation. However, its specific regulatory mechanisms and broader biological roles remain under investigation, highlighting the need for continued exploration using targeted antibodies.