KCNU1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06806(KCNU1 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The KCNU1 antibody is a research tool designed to detect the KCNU1 protein, a subunit of potassium channels encoded by the *KCNU1* gene (also known as *Slo3* or *KCa5.1*). KCNU1 belongs to the Slo family of voltage- and ion-sensitive potassium channels, which regulate cellular excitability and ion homeostasis. Unlike the widely expressed BK channels (Slo1/KCNMA1), KCNU1 is primarily found in sperm cells, where it forms pH-sensitive channels critical for sperm motility and male fertility. These channels activate under alkaline conditions in the female reproductive tract, facilitating hyperpolarization and capacitation during fertilization.

KCNU1 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. They enable the study of KCNU1 expression, localization, and function through techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Validated applications often include specificity checks via knockout controls or siRNA knockdown. Research involving KCNU1 antibodies has highlighted its role in reproductive biology, particularly in understanding male infertility linked to channel dysfunction. Dysregulation of KCNU1 may also be explored in broader contexts, such as ion channelopathies or pH-dependent cellular processes. Current studies focus on elucidating structural mechanisms, modulators, and potential therapeutic targets for fertility-related disorders.