KCNK15抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human muscle tissue lysate, Primary antibody: P06800(KCNK15 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P06800(KCNK15 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The KCNK15 antibody is a research tool designed to detect and study potassium channel subfamily K member 15 (KCNK15), a protein encoded by the *KCNK15* gene. KCNK15. also known as TASK-5. belongs to the two-pore domain (K2P) potassium channel family, which regulates background potassium currents to maintain resting membrane potential and cellular excitability. Structurally, KCNK15 contains four transmembrane domains and two pore-forming loops, typical of K2P channels. While its functional role remains less characterized compared to other K2P channels, studies suggest pH sensitivity and involvement in physiological processes like hormone secretion and neuronal signaling.

KCNK15 antibodies are primarily used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate protein expression, localization, and tissue distribution. Research indicates KCNK15 expression in adrenal glands, pancreas, and brain, hinting at potential roles in endocrine or neurological functions. Aberrant expression has been explored in diseases, including certain cancers, though its pathological significance is not fully established.

These antibodies aid in elucidating KCNK15's interaction networks, regulatory mechanisms (e.g., phosphorylation), and potential as a therapeutic target. Challenges include limited commercial availability and specificity validation due to sequence homology within the K2P family. Ongoing studies aim to clarify its physiological impact and relevance in human health, positioning KCNK15 antibodies as critical tools for advancing potassium channel biology.