KBTBD11抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human metastatic papillary carcinoma(thyroid cancer) tissue lysate, Primary antibody: P06794(KBTBD11 Antibody) at dilution 1/2300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

The KBTBD11 (Kelch Repeat and BTB Domain Containing 11) protein is a member of the Kelch superfamily, characterized by its N-terminal BTB (Bric-a-brac, Tramtrack, Broad Complex) domain and C-terminal Kelch repeat motifs. These structural features enable KBTBD11 to participate in protein-protein interactions, potentially serving as a substrate adaptor for Cullin 3 (CUL3)-based E3 ubiquitin ligase complexes. This suggests a role in ubiquitination-mediated protein degradation, a critical regulatory mechanism in cellular processes like cell cycle control and stress response.

KBTBD11 is encoded by a gene located on chromosome 8 (8q24.3) and is expressed in various tissues, with emerging links to neurodevelopment and cancer. Studies associate KBTBD11 dysregulation with intellectual disability and developmental delay syndromes, possibly through disrupted ubiquitination pathways affecting neuronal signaling. In oncology, reduced KBTBD11 expression has been observed in colorectal and lung cancers, implicating it as a potential tumor suppressor. Its interaction with pathways like Notch and Wnt underscores its multifaceted regulatory influence.

KBTBD11 antibodies are essential tools for detecting and quantifying the protein in research applications, including Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in elucidating KBTBD11’s tissue distribution, subcellular localization, and expression changes in disease models. While therapeutic applications remain exploratory, understanding KBTBD11’s molecular interactions through antibody-based studies could reveal novel targets for neurological disorders or cancer treatment strategies. Current research focuses on validating antibody specificity and optimizing detection protocols to minimize cross-reactivity with related Kelch family proteins.