多巴胺受体D2抗体

英文名称Rabbit Anti-DRD2  antibody

中文名称多巴胺受体D2抗体

别    名DRD2_HUMAN; D(2) dopamine receptor; Dopamine D2 receptor; dopamine receptor D2; D2R; D2DR;   

研究领域肿瘤  免疫学  神经生物学  信号转导  细胞膜受体  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human,Mouse,Rat (predicted: Rabbit,Sheep,Cow,Dog,Horse)

产品应用WB=1:500-2000,ELISA=1:5000-10000

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

理论分子量51kDa

细胞定位细胞膜 

性    状Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human DRD2: 1-100/443 <Extracellular>

亚    型IgG

纯化方法affinity purified by Protein A

缓 冲 液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PubMedPubMed

产品介绍This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]

Function:

This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Subcellular Location:

Cell membrane.

DISEASE:

Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.

Similarity:

Belongs to the G-protein coupled receptor 1 family.

SWISS:

P14416

Gene ID:

1813