L-生物蝶呤

Product Name:L-Biopterin(NSC 339699;6-Biopterin)
Appearance:Colorless to pale yellow powder
Purity(HPLC): min98.0%
Product Name: L-Biopterin; 6-Biopterin
CAS No.: 22150-76-1
Synonyms: 6-Biopterin,NSC 339699, L-erythro-Biopterin;   (1'R,2'S)-Biopterin; 2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine
Chemical Name: 2-amino-6-(1,2-dihydroxypropyl)-1H-pteridin-4-one
Molecular Formula: C₉H₁₁N₅O₃
Molecular Weight: 237.22
Product Description:
L-Biopterin is the oxidized form of tetrahydro-L-biopterin (BH₄), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH₄ via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC₅₀ = 0.2 µM after 48 hrs). L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.

L-Biopterin is an important cofactor in the production of many essential neurotransmitters, such as dopamine, seratonin and epinephrine, and plays an important role in the production of nitric oxide in the body. It is produced as an oxidation product by the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). L-Biopterin has been shown to be cytotoxic to melanocytes in vitro, and may be a useful noninvasive biomarker.

Applications: A pteridine widely distributed in nature; naturally occurring as the L-erythro-form. Considered as a growth factor for some insects. Fluoresces with a blue color in alkaline solution. A cofactor in the production of many neurotransmitters and nitric oxide.

6-Biopterin is an oxidation product from the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). In vitro, 6-Biopterin is cytotoxic to melanocytes. However, in vivo, 6-Biopterin is rapidly and sequentially reduced back to 6-GH4 via q-BH2. Recent studies suggest that 6-Biopterin among other pteridines may be a useful non-invasive biomarker for cancer.

Synonyms: NSC 339699; 6-Biopterin; L-Erythro-biopterin; (1'R,2'S)-Biopterin;2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine;2-amino-6-(1,2-dihydroxypropyl)pteridin-4(1H)-one;2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]pteridin-4(1H)-one;2-amino-7-(1,2-dihydroxypropyl)pteridin-4(1H)-one
CAS No: 22150-76-1
Molecular Formula: C₉H₁₁N₅O₃
Molecular Weight: 237.22
Appearance: Colorless to pale yellow powder
Storage: Store in cool dark place keep away from the sunshine light.