卡巴他赛

Product Name: Cabazitaxel(XRP-6258); Cabazitaxel; 7β,10β-Dimethoxydocetaxel; TXD 258; XRP 6258; XRP6258; RPR-116258A;
Taxoid XRP6258; TXD-258; XRP-6258; RPR-116258; Jevtana
CAS No.:183133-96-2
Molecular Formula: C₄₅H₅₇NO₁₄
Molecular Weight: 835.93
Appearance:White to off white crystalline powder
Purity(HPLC):NLT99.0%
Biological Activity:  Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).