IST1抗体—艾普蒂

The IST1 antibody targets the IST1 (Increased Sodium Tolerance 1 homolog) protein, a component of the endosomal sorting complex required for transport (ESCRT) machinery. IST1 plays a critical role in membrane remodeling processes, such as cytokinesis, multivesicular body (MVB) formation, and viral budding, by facilitating the assembly and disassembly of ESCRT-III polymers. It interacts with other ESCRT components, including CHMP1B and VPS4. to regulate membrane scission and cargo sorting. IST1 antibodies are widely used in research to investigate cellular division, intracellular trafficking, and organelle biogenesis. They are applied in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to study IST1 expression, localization, and interactions. Dysregulation of IST1 or ESCRT pathways is linked to neurological disorders, cancer, and infectious diseases, making this antibody a valuable tool for exploring disease mechanisms. Recent studies also highlight its role in autophagy and lysosomal function, expanding its relevance in cellular homeostasis research.