IP6K1抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of B16 cells using CD51 mouse mAb (green) and negative control (red).    

  
  

The IP6K1 antibody is a crucial tool for studying inositol hexakisphosphate kinase 1 (IP6K1), an enzyme involved in synthesizing inositol pyrophosphates like 5-diphosphoinositol pentakisphosphate (5-IP7). IP6K1 belongs to the IP6K family (IP6K1-3), which regulates cellular processes such as energy metabolism, apoptosis, insulin secretion, and chromatin remodeling. IP6K1 catalyzes the phosphorylation of IP6 to 5-IP7. a high-energy signaling molecule influencing vesicular trafficking, telomere maintenance, and stress responses. Dysregulation of IP6K1 is linked to metabolic disorders, neurodegenerative diseases, and cancer, making it a therapeutic target.

IP6K1 antibodies are designed to detect endogenous IP6K1 protein levels, localization, and expression patterns in various tissues or cell lines. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). Specificity is validated through knockout controls or siRNA-mediated knockdown. These antibodies often target conserved regions, such as the catalytic domain or unique C-/N-terminal sequences, to distinguish IP6K1 from homologs (e.g., IP6K2/3). Research applications include exploring IP6K1's role in metabolic pathways (e.g., diabetes), cancer cell proliferation, and neurological functions, aiding in mechanistic studies and drug discovery.