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  • IFNA5抗体—艾普蒂
  • IFNA5抗体—艾普蒂
  • IFNA5抗体—艾普蒂

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IFNA5抗体—艾普蒂

Rabbit Polyclonal IFNA5 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-18

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：rui***

产品详情:

中文名称：
IFNA5抗体
英文名称：
Rabbit Polyclonal IFNA5 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3236 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
IFNA5

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesT11; SRBC; LFA-2
Entrez GeneID914
clone3D1E3
WB Predicted band size39.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityMouse
ImmunogenPurified recombinant fragment of human CD2 (AA: 25-140) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using CD2 mouse mAb against MOLT4 (1), MCF-7 (2), L1210 (3), U937 (4), and NIH3T3 (5) cell lysate.    


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       Flow cytometric analysis of Hela cells using CD2 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HepG2 cells using CD2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CD2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using CD2 mouse mAb with DAB staining.    


           

参考文献

以下是关于IFNA5抗体的假设性参考文献示例(请注意，这些文献为虚构示例，实际引用需查询真实数据库)：

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1. **文献名称**: *"Development of a Monoclonal Antibody Specific for Human IFNA5 and Its Application in Detecting Interferon Expression Profiles"*

**作者**: Smith A, et al.

**摘要**: 本研究开发了一种高特异性抗人IFNA5的单克隆抗体，用于区分IFNA5与其他I型干扰素亚型。通过ELISA和免疫组化验证，该抗体成功应用于病毒感染模型中IFNA5的蛋白表达定位，揭示了其在抗病毒反应中的独特表达模式。

2. **文献名称**: *"IFNA5 Neutralizing Antibody Attenuates Autoimmune Inflammation in a Murine Model"*

**作者**: Chen L, et al.

**摘要**: 文章报道了一种中和性IFNA5抗体在自身免疫性疾病模型中的应用。实验表明，阻断IFNA5可显著减少Th17细胞介导的炎症反应，提示IFNA5可能成为治疗类风湿性关节炎等疾病的潜在靶点。

3. **文献名称**: *"Epitope Mapping of IFNA5 Using Polyclonal Antibodies Reveals Functional Domains"*

**作者**: Tanaka K, et al.

**摘要**: 通过多克隆抗体对IFNA5的表位进行定位分析，发现其C端区域对受体结合至关重要。该研究为设计靶向IFNA5的抗体药物提供了结构生物学依据。

4. **文献名称**: *"Differential Expression of IFNA5 in Tumor Microenvironments Identified by Immunohistochemical Staining"*

**作者**: Müller R, et al.

**摘要**: 利用商业化IFNA5抗体对多种癌症组织进行染色，发现IFNA5在肿瘤相关成纤维细胞中高表达，提示其可能通过调控肿瘤微环境影响免疫治疗效果。

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**备注**：以上文献为示例性质，实际研究中请通过PubMed、Web of Science等平台检索真实文献(如搜索关键词：IFNA5 antibody, interferon alpha 5 antibody)。若需具体文献协助，建议提供更详细的研究方向。

       

背景信息

The interferon alpha 5 (IFNA5) protein is a member of the type I interferon (IFN) family, which plays a critical role in innate immunity against viral infections and tumor surveillance. Encoded by the IFNA5 gene, it shares structural homology with other IFN-α subtypes but exhibits distinct receptor-binding affinities and downstream signaling activities. IFNA5 signals through the IFN-α/β receptor (IFNAR), activating JAK-STAT pathways to induce interferon-stimulated genes (ISGs) that mediate antiviral, antiproliferative, and immunomodulatory effects.

Antibodies targeting IFNA5 are essential tools for studying its expression, function, and regulation in both physiological and pathological contexts. They enable detection of IFNA5 in biological samples (e.g., ELISA, Western blot) and localization in tissues (e.g., immunohistochemistry). Such antibodies are particularly relevant in research on autoimmune diseases (e.g., lupus), viral infections, and cancers, where dysregulated IFN signaling is implicated. Additionally, neutralizing IFNA5 antibodies may have therapeutic potential for mitigating IFN-driven pathologies. Commercial IFNA5 antibodies vary in specificity (monoclonal vs. polyclonal), host species, and applications, requiring validation to avoid cross-reactivity with other IFN-α subtypes. Recent studies also explore IFNA5's unique role in tumor microenvironments and its biomarker potential, underscoring the importance of reliable antibody reagents in advancing IFN-related research.

       
IFNA5抗体;IFNA5;IFNA5 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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