IER5抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P06726(IER5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P06726(IER5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The IER5 (Immediate Early Response 5) antibody is a tool used to study the IER5 protein, encoded by the IER5 gene, which belongs to the immediate-early response family. These genes are rapidly induced by cellular stress signals, including DNA damage, heat shock, or growth factor stimulation. IER5 is implicated in regulating cell cycle progression, apoptosis, and stress adaptation. It interacts with key pathways such as the p53 signaling network and modulates the activity of heat shock factor 1 (HSF1), influencing heat shock protein (HSP) expression during stress conditions.

Research highlights IER5's role in cancer biology, where its expression fluctuates in response to radiation or chemotherapy, suggesting involvement in therapeutic resistance. It also participates in maintaining genomic stability by promoting DNA repair. The IER5 antibody enables detection and quantification of IER5 protein levels in tissues or cultured cells, facilitating studies on its subcellular localization, expression dynamics under stress, and interactions with partner proteins. Applications include Western blotting, immunofluorescence, and immunohistochemistry. Understanding IER5's function through antibody-based assays may reveal therapeutic targets for cancers or stress-related disorders. Commercial IER5 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown to ensure reliability in experimental models.