HOXD9抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cell lysate, Primary antibody: P06713(HOXD9 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

The HOXD9 antibody is a research tool designed to detect and study the HOXD9 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors critical for embryonic development, particularly in establishing body patterning and cellular differentiation. HOXD9. located on chromosome 2q31. regulates target genes by binding to specific DNA sequences, influencing processes like limb formation, skeletal development, and organogenesis. Dysregulation of HOXD9 has been implicated in cancer, where it may act as an oncogene or tumor suppressor depending on context. For example, elevated HOXD9 expression is linked to metastasis in breast and colorectal cancers, while its downregulation is observed in gliomas.

HOXD9 antibodies are typically monoclonal or polyclonal reagents produced in hosts like rabbits or mice. They enable the visualization and quantification of HOXD9 protein levels in techniques such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are essential for exploring HOXD9's role in developmental biology, disease mechanisms, and potential therapeutic targeting. Researchers must validate antibody specificity using knockout controls or peptide-blocking assays, as cross-reactivity with other HOX family members is a common concern. Recent studies also highlight HOXD9's involvement in cellular senescence and stem cell regulation, expanding its relevance beyond developmental contexts. Proper antibody selection and optimization are crucial for reliable experimental outcomes in both basic and translational research.