HOXC12抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cell lysate, Primary antibody: P06710(HOXC12 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P06710(HOXC12 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P06710(HOXC12 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The HOXC12 antibody is a research tool designed to detect the HOXC12 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors critical for embryonic development, particularly in establishing body axis patterning, organogenesis, and limb formation. HOXC12. located on chromosome 12 within the HOXC cluster, contains a conserved homeodomain that binds DNA to regulate target gene expression. It plays roles in skeletal development, cell differentiation, and tissue remodeling, with expression patterns often tissue- and stage-specific.

HOXC12 antibodies are widely used in immunohistochemistry (IHC), Western blotting, and immunofluorescence (IF) to study HOXC12’s spatial-temporal expression, localization, and interactions in developmental and disease contexts. Dysregulation of HOXC12 has been linked to cancers (e.g., breast, prostate, and leukemia) due to its influence on proliferation, apoptosis, and metastasis. Antibodies enable researchers to explore HOXC12’s oncogenic or tumor-suppressive roles, depending on cellular context.

Additionally, HOXC12 antibodies aid in understanding congenital disorders. Mutations or aberrant HOXC12 expression correlate with skeletal malformations and neurological defects. Recent studies also implicate HOXC12 in metabolic regulation and stem cell maintenance, expanding its relevance beyond developmental biology. As a reagent, HOXC12 antibodies must be validated for specificity, as cross-reactivity with other HOX proteins is a common challenge. Their application continues to advance insights into HOX-mediated gene networks and therapeutic targeting opportunities.