EOGT抗体—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P06681(EOGT Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The EOGT (ER-resident O-linked N-acetylglucosamine transferase) antibody is a critical tool for studying the enzyme responsible for O-GlcNAcylation, a post-translational modification of proteins. Unlike the nucleocytoplasmic OGT, EOGT is localized in the endoplasmic reticulum and specifically catalyzes the addition of O-linked GlcNAc to extracellular domains of target proteins, such as Notch receptors. This modification plays a vital role in regulating cellular signaling pathways, particularly the Notch pathway, which influences cell differentiation, development, and tissue homeostasis. Mutations in EOGT are linked to genetic disorders like Adams-Oliver syndrome, underscoring its biological importance.

EOGT antibodies enable researchers to detect and quantify EOGT expression in various tissues and experimental models. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate EOGT’s spatial distribution, interaction partners, and regulatory mechanisms. These antibodies also aid in exploring EOGT’s involvement in diseases, including congenital defects, metabolic disorders, and cancer. By facilitating the study of O-GlcNAc dynamics in the secretory pathway, EOGT antibodies contribute to understanding how glycosylation impacts protein function, cellular communication, and disease pathogenesis. Their specificity is often validated through knockout controls, ensuring reliability in experimental settings.