GRIPAP1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P06649(GRIPAP1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

**Background of GRIPAP1 Antibody**

GRIPAP1 (GRIP1-associated protein 1), also known as PRRT2 (proline-rich transmembrane protein 2), is a neural protein that interacts with GRIP1 (glutamate receptor-interacting protein 1), a scaffolding protein involved in the trafficking and synaptic anchoring of AMPA-type glutamate receptors. GRIPAP1/PRRT2 is predominantly expressed in the brain and plays roles in synaptic plasticity, neurotransmitter release, and neuronal signaling.

Mutations in the *PRRT2* gene are linked to neurological disorders, including paroxysmal kinesigenic dyskinesia (PKD), benign familial infantile epilepsy (BFIE), and infantile convulsions with choreoathetosis (ICCA). These findings highlight its importance in regulating neuronal excitability.

GRIPAP1 antibodies are essential tools for studying the protein's expression, localization, and function in neural tissues. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate GRIPAP1/PRRT2 in disease models, synaptic protein complexes, and its interaction with GRIP1 or other partners. Such research aids in unraveling pathogenic mechanisms of PRRT2-related disorders and potential therapeutic targets.