GPR137抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: TM4, PC3 and NIH/3T3 cell lysates, Human cerebrum tissue lysates, Primary antibody: P06626(GPR137 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

**Background of GPR137 Antibody**

GPR137 (G protein-coupled receptor 137) is an orphan receptor belonging to the G protein-coupled receptor (GPCR) family, characterized by its seven transmembrane domains. Although its endogenous ligand and precise physiological roles remain unclear, GPR137 is implicated in regulating cellular processes such as proliferation, apoptosis, and differentiation. Research suggests its potential involvement in cancer progression, with studies reporting overexpression in malignancies like prostate, liver, and colorectal cancers, where it may influence tumor growth and metastasis.

GPR137 antibodies are essential tools for detecting and studying the expression, localization, and function of this receptor. These antibodies are typically developed using immunogenic peptides derived from specific regions of the GPR137 protein (e.g., extracellular or intracellular domains) and validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. High-quality GPR137 antibodies exhibit specificity, sensitivity, and reproducibility, enabling researchers to explore its role in disease mechanisms.

Recent studies emphasize GPR137's potential as a therapeutic target or diagnostic biomarker, driving the demand for reliable antibodies. However, challenges persist due to the receptor's orphan status and limited functional data. Ongoing research aims to unravel GPR137's signaling pathways and interactions, which could unlock novel clinical applications.