ENAH抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P06610(ENAH Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The ENAH (Enabled homolog) antibody is a tool used to detect ENAH protein, a member of the Ena/VASP (Enabled/Vasodilator-Stimulated Phosphoprotein) family involved in actin cytoskeleton regulation. ENAH, encoded by the *ENAH* gene, plays a critical role in cell motility, adhesion, and morphogenesis by promoting actin polymerization and filament elongation. It interacts with signaling pathways to coordinate cytoskeletal dynamics during processes like embryonic development, wound healing, and cancer metastasis.

ENAH exists in multiple splice variants (e.g., ENAH-V1. V2), with differential roles in cellular behavior. Overexpression of ENAH is linked to tumor progression, particularly in cancers such as breast, colon, and pancreatic adenocarcinoma, where it enhances invasive potential. This makes ENAH a biomarker of interest in oncology research.

The ENAH antibody is widely used in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to study its expression, localization, and function in normal and pathological tissues. Researchers also employ it to explore ENAH's interaction with binding partners (e.g., Rho GTPases) and its role in epithelial-mesenchymal transition (EMT). Validated antibodies are essential for distinguishing between isoforms and ensuring specificity in experimental models, aiding both basic research and translational studies targeting metastatic pathways.