ARHGEF18抗体—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P06608(ARHGEF18 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P06608(ARHGEF18 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of ARHGEF18 Antibody**

ARHGEF18 (Rho/Rac Guanine Nucleotide Exchange Factor 18), also known as p114RhoGEF, is a member of the RhoGEF family that activates Rho GTPases by catalyzing the exchange of GDP for GTP. It specifically regulates RhoA and RhoB, playing critical roles in cytoskeletal reorganization, cell polarity, and junctional complex assembly. Structurally, ARHGEF18 contains a conserved DH (Dbl-homology) domain responsible for GEF activity and a PH (Pleckstrin-homology) domain involved in membrane targeting and regulatory interactions.

In epithelial and endothelial cells, ARHGEF18 is essential for maintaining apical-basal polarity and stabilizing tight junctions. Studies highlight its interaction with partitioning-defective (PAR) proteins, linking Rho signaling to cell polarity establishment. Dysregulation of ARHGEF18 is implicated in pathological conditions, including inflammatory bowel disease (IBD), vascular dysfunction, and cancer metastasis, where disrupted cell adhesion and barrier integrity contribute to disease progression.

ARHGEF18 antibodies are vital tools for investigating its expression, localization, and function. They enable detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding studies on tissue-specific roles or signaling mechanisms. Validated antibodies help identify ARHGEF18’s involvement in Rho-dependent pathways, offering insights into therapeutic targets for diseases linked to cytoskeletal or junctional defects. Research utilizing these antibodies continues to unravel its complex regulatory networks in health and disease.