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  • ROMO1抗体—艾普蒂
  • ROMO1抗体—艾普蒂
  • ROMO1抗体—艾普蒂

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ROMO1抗体—艾普蒂

Rabbit Polyclonal ROMO1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-18

上海切尔齐生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
ROMO1抗体
英文名称：
Rabbit Polyclonal ROMO1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3184 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
ROMO1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesMTGM; MTGMP; C20orf52; bA353C18.2
WB Predicted band size8 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human ROMO1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Mouse heart tissue, Human heart tissue, HEPG2 cell, PC-3 cell, 231 cell and 293T cell lysates, Primary antibody: P06607(ROMO1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P06607(ROMO1 Antibody) at dilution 1/25. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P06607(ROMO1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于ROMO1抗体的3篇代表性文献的模拟示例(基于公开知识，非真实引用)：

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1. **"Role of ROMO1 in mitochondrial reactive oxygen species generation and apoptosis signaling"**

*Chung YM et al. (2011)*

摘要：研究利用特异性ROMO1抗体验证其在调控线粒体ROS生成中的作用，发现ROMO1通过激活NF-κB通路促进癌细胞凋亡抵抗，抗体用于Western blot和免疫荧光定位线粒体表达。

2. **"ROMO1 as a potential therapeutic target in colorectal cancer progression"**

*Kim JH et al. (2015)*

摘要：通过抗ROMO1抗体检测结直肠癌组织中ROMO1高表达，证实其与患者预后不良相关，并揭示其通过ROS依赖的MAPK通路驱动肿瘤侵袭转移。

3. **"Development of a monoclonal antibody against human ROMO1 for oxidative stress studies"**

*Lee S et al. (2018)*

摘要：报道一种新型单克隆ROMO1抗体的开发与验证，应用于流式细胞术和免疫组化，证明其在神经退行性疾病模型中可定量检测氧化应激诱导的ROMO1上调。

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注：以上为基于ROMO1已知功能的模拟文献，实际引用需通过PubMed、Google Scholar等平台以“ROMO1 antibody”或“ROMO1 function”为关键词检索真实论文。

       

背景信息

ROMO1 (Reactive Oxygen Modulator 1), also known as CCDC111 or HMO-Sh, is a mitochondrial membrane protein implicated in regulating reactive oxygen species (ROS) production and mitochondrial dynamics. First identified in 2005. it plays a critical role in maintaining mitochondrial membrane potential, apoptosis, and cellular stress responses. Dysregulation of ROMO1 is linked to various pathologies, including cancer progression, neurodegenerative diseases, and metabolic disorders. Its overexpression has been observed in multiple cancers, where it promotes tumor growth and chemoresistance by enhancing ROS-mediated signaling pathways.

ROMO1 antibodies are essential tools for studying its expression, localization, and function. These antibodies (polyclonal or monoclonal) are typically developed against specific epitopes of human ROMO1 and validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use them to investigate ROMO1's interaction partners, such as components of the mitochondrial permeability transition pore, and its role in oxidative stress pathways. Recent studies also explore ROMO1 as a potential therapeutic target, driving demand for reliable antibodies in both diagnostic and drug development contexts. However, challenges remain in ensuring antibody specificity due to ROMO1's structural similarities with other mitochondrial proteins.

       
ROMO1抗体;ROMO1;ROMO1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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