GPR1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P06587(GPR1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P06587(GPR1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P06587(GPR1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The GPR1 antibody is a research tool designed to target G protein-coupled receptor 1 (GPR1), a member of the large GPCR family involved in cellular signaling. GPR1. first identified in the 1990s, is an orphan receptor with no well-characterized endogenous ligand. It shares structural homology with chemokine receptors and is implicated in processes like inflammation, metabolism, and immune regulation. Although its exact physiological role remains unclear, studies suggest GPR1 may interact with ligands such as chemerin or resolvins, influencing adipogenesis, insulin sensitivity, and macrophage function.

GPR1 antibodies are primarily used to detect and study the receptor's expression, localization, and function in experimental models. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize GPR1 in tissues or cultured cells. Researchers employ these antibodies to explore GPR1's potential roles in diseases, including cancer (e.g., tumor microenvironment modulation), neurodegenerative disorders, and metabolic syndromes. Commercial GPR1 antibodies are often raised in rabbits or mice, targeting specific epitopes like extracellular or intracellular domains. Validation data, including knockout controls, are critical due to occasional cross-reactivity issues. Recent interest in GPR1 stems from its possible therapeutic relevance, though further studies are needed to clarify its signaling mechanisms and pathophysiological significance.