GALP抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue and Mouse thymus tissue lysates, Primary antibody: P06547(GALP Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P06547(GALP Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

GALP (Galanin-like peptide) antibody is a tool used to detect and study GALP, a neuropeptide involved in regulating energy homeostasis, feeding behavior, and reproductive functions. GALP, structurally related to galanin, is predominantly expressed in the hypothalamic arcuate nucleus and binds to galanin receptors with distinct affinity. It plays a role in mediating leptin's effects on metabolism, linking adipose-derived signals to neural circuits. Research on GALP has implications for understanding obesity, diabetes, and reproductive disorders.

Antibodies against GALP enable localization and quantification of the peptide in tissues, aiding studies on its distribution, secretion dynamics, and interaction with receptors. Developing specific GALP antibodies is challenging due to sequence similarities with other galanin-family peptides. Validated antibodies are essential for distinguishing GALP’s unique physiological roles.

Current applications include immunohistochemistry, Western blotting, and ELISA to explore GALP expression patterns in disease models. Recent studies also investigate GALP’s potential role in inflammation and neurodegenerative conditions. However, cross-reactivity remains a concern, necessitating rigorous validation. Continued refinement of GALP-specific antibodies will enhance precision in unraveling its complex regulatory networks and therapeutic potential.