FUT10抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue lysate, Primary antibody: P06540(FUT10 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P06540(FUT10 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

FUT10 (Fucosyltransferase 10) is an enzyme belonging to the glycosyltransferase family, specifically catalyzing the transfer of fucose residues to glycoproteins and glycolipids via α1.3-linkages during post-translational modifications. It plays a critical role in synthesizing Lewis antigens and other fucosylated glycoconjugates involved in cell-cell interactions, immune responses, and signal transduction. FUT10 is primarily expressed in epithelial tissues and has been implicated in various physiological and pathological processes, including cancer progression, inflammation, and developmental regulation.

FUT10 antibodies are immunological tools designed to detect and quantify FUT10 protein expression in research applications. They are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study tissue-specific expression patterns, subcellular localization, and dysregulation in diseases. Such antibodies often target specific epitopes within the enzyme's catalytic domain or variable regions. Studies utilizing FUT10 antibodies have contributed to understanding its role in tumor metastasis (e.g., through modulating E-cadherin fucosylation) and congenital disorders of glycosylation. Validation of these antibodies typically includes knockout controls and activity assays to ensure specificity, given the structural similarities among fucosyltransferase family members. Their development supports ongoing exploration of FUT10 as a potential biomarker or therapeutic target in glycosylation-related diseases.